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  Indian J Med Microbiol
 

Figure 1 Photograph of transverse sections (TC) of carotid artery. (Slide I): TC of carotid artery of control group (group I) showing normal histological structures of intima, media, and adventitia. (Slide IIa): TC of carotid artery of group IIa shows atherogenic changes in form of marked intimal thickening and subintimal atheromatous plaque (a) with atheromatous cap formation formed of foamy histocytes (b), fibrous bands, and scattered inflammatory cells (c) with ulceration of intimal lining (d). (Slide IIb): TC of carotid artery of group IIb shows that methotrexate administration prevented to a large extent the development of atherosclerotic changes as indicated by very thin atheromatous plaque with less inflammatory cellular infiltration and some foam cells formation with nearly normal thickness of media. (Slide IIc): TC of carotid artery of group IIc shows that cholestyramine produced slight improvement in the atherogenic changes in the form of slight reduction in the thickness of subintimal atheromatous plaque (↑) with needle-like cholesterol clefts formation, foamy histocytes, fibrous bands, and inflammatory cells infiltration with intimal ulceration (a), thickening, and protrusion in the lumen (b). (Slide IId): TC of carotid artery of group IId shows that simvastatin administration prevented to a large extent the development of atherosclerotic changes as indicated by minimal intimal thickening, less inflammatory cellular infiltration, less foam cells, and less cholesterol clefts with nearly normal thickness of media.

Figure 1 Photograph of transverse sections (TC) of carotid artery. (Slide I): TC of carotid artery of control group (group I) showing normal histological structures of intima, media, and adventitia. (Slide IIa): TC of carotid artery of group IIa shows atherogenic changes in form of marked intimal thickening and subintimal atheromatous plaque (a) with atheromatous cap formation formed of foamy histocytes (b), fibrous bands, and scattered inflammatory cells (c) with ulceration of intimal lining (d). (Slide IIb): TC of carotid artery of group IIb shows that methotrexate administration prevented to a large extent the development of atherosclerotic changes as indicated by very thin atheromatous plaque with less inflammatory cellular infiltration and some foam cells formation with nearly normal thickness of media. (Slide IIc): TC of carotid artery of group IIc shows that cholestyramine produced slight improvement in the atherogenic changes in the form of slight reduction in the thickness of subintimal atheromatous plaque (↑) with needle-like cholesterol clefts formation, foamy histocytes, fibrous bands, and inflammatory cells infiltration with intimal ulceration (a), thickening, and protrusion in the lumen (b). (Slide IId): TC of carotid artery of group IId shows that simvastatin administration prevented to a large extent the development of atherosclerotic changes as indicated by minimal intimal thickening, less inflammatory cellular infiltration, less foam cells, and less cholesterol clefts with nearly normal thickness of media.