Al-Azhar Assiut Medical Journal

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 15  |  Issue : 3  |  Page : 135--141

Evaluation of serum ferritin level in patients with fever of unknown origin


Raed Hamed Mansour1, Shaban Salah Abd El-moneum1, Tarek Aly Hassan2, Ahmed Abdelalim Abuo Elhassan1, Mohamed Hasan Elnadry1, Wlid Mohamed Elbakrawy3 
1 Professor, Tropical Medicine Department, Al Azhar University, Cairo, Egypt
2 Professor of Biochemisry, Al Azhar University, Cairo, Egypt
3 Tropical Medicine Specialist, Ministry of Health

Correspondence Address:
Raed Hamed Mansour
Tropical Medicine Department, Alhosin Hospital, Cairo
Egypt

Background Diagnosis of the cause of fever of unknown origin (FUO) is a great challenge. Serum ferritin may be a useful index for differentiating between infectious and noninfectious causes of FUO (malignant disease or collagen disease). In this respect, serum ferritin has the advantage of decreasing the number of unnecessary tests and helping to exclude infectious disease. Objective This study aimed to evaluate serum ferritin levels among patients suffering from FUO. Methods A comparison was made between infectious, noninfectious, and undiagnosed cases of FUO as regards serum ferritin level using an in-vitro enzyme-linked immunosorbent assay. Results The most common causes of FUO were infectious diseases (120/300, 40%), followed by noninfectious diseases such as malignant (61/300, 20.4%) and autoimmune causes (49/300, 16.3%). Undiagnosed cases constituted 70/300 (23.3%). The mean serum ferritin level in the infectious group, noninfectious group, and undiagnosed group was 99.25±49.58, 1098.94±284.54, and 112.40±183.23, respectively, with highly significant difference between infectious and noninfectious causes of FUO (P<0.001). However, there were no significant differences between infectious and undiagnosed causes of FUO. The optimal cutoff point was 559.0; the area under the curve was 0.79, with highly significant difference (P<0.001) at 95% confidence interval of 0.71–0.88. Conclusion High serum ferritin level (>559 ng/ml) helps in differentiation between infectious and noninfectious causes of FUO. In undiagnosed cases of FUO we must direct our thinking to infectious diseases.


How to cite this article:
Mansour RH, Abd El-moneum SS, Aly Hassan T, Abuo Elhassan AA, Elnadry MH, Elbakrawy WM. Evaluation of serum ferritin level in patients with fever of unknown origin.Al-Azhar Assiut Med J 2017;15:135-141


How to cite this URL:
Mansour RH, Abd El-moneum SS, Aly Hassan T, Abuo Elhassan AA, Elnadry MH, Elbakrawy WM. Evaluation of serum ferritin level in patients with fever of unknown origin. Al-Azhar Assiut Med J [serial online] 2017 [cited 2018 Jul 23 ];15:135-141
Available from: http://www.azmj.eg.net/article.asp?issn=1687-1693;year=2017;volume=15;issue=3;spage=135;epage=141;aulast=Mansour;type=0