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 Table of Contents  
Year : 2020  |  Volume : 18  |  Issue : 2  |  Page : 111

Interleukin-6 gene polymorphism and rheumatoid arthritis

1 26 Medical Center, Bangkok, Thailand
2 Department of Community Medicine, Dr DY Patil University, Pune, India

Date of Submission24-Oct-2019
Date of Decision29-Oct-2019
Date of Acceptance20-Jan-2020
Date of Web Publication24-Jul-2020

Correspondence Address:
Rujittika Mungmunpuntipantip
26 Medical Center, Bangkok 10150
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/AZMJ.AZMJ_146_19

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How to cite this article:
Mungmunpuntipantip R, Wiwanitkit V. Interleukin-6 gene polymorphism and rheumatoid arthritis. Al-Azhar Assiut Med J 2020;18:111

How to cite this URL:
Mungmunpuntipantip R, Wiwanitkit V. Interleukin-6 gene polymorphism and rheumatoid arthritis. Al-Azhar Assiut Med J [serial online] 2020 [cited 2020 Oct 20];18:111. Available from: http://www.azmj.eg.net/text.asp?2020/18/2/111/290600

Dear editor,

We read the publication on ‘Study of the effect of interleukin (IL)-6 gene polymorphism in patients with rheumatoid arthritis (RA)’ with great interest [1]. Sedira et al. [1] have noted that ‘The GC and CC genotype and C allele of IL-6 (−174G/C) may represent a significant genetic molecular marker to predict the risk of RA.’ Indeed, this study focused on single-gene polymorphism. There might be other effects from other genetic polymorphisms that might affect RA (such as APOE, HLA-G 3’UTR, and TRAF1/C5 polymorphisms) [2],[3],[4]. Regarding the effect of IL-6 (−174G/C), the molecular mechanism underlying the pathogenesis is the molecular change due to single mutation. As described in a previous study on IL-18 (−137G/C) [5], the G/C change results in decreased molecular weight equal to −40.03 g/mol. This pathobiological process is the same as that described in the study on the effect of IL polymorphism on other medical disorders [5].

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There are no conflicts of interest.

  References Top

Sedira MH, Seoudy OA, Ahmed LA, El Attar S, Mohamed EF. Study of the effect of interleukin-6 gene polymorphism in patients with rheumatoid arthritis. Al-Azhar Assiut Med J 2019; 17:182–189  Back to cited text no. 1
Gauri LA, Singh U, Kapur S, Fatima Q, Ranwa B, Khan A et al. Study of APOE gene and D2S439 marker in patients of rheumatoid arthritis and their correlation with severity of disease: a case control study. J Assoc Physicians India 2019; 67:43–48.  Back to cited text no. 2
Gautam S, Kumar U, Kumar M, Kanga U, Dada R. Association of HLA-G 3’UTR polymorphisms with soluble HLA-G levels and disease activity in patients with rheumatoid arthritis: a case-control study. Immunol Invest 2019; 49:1–18.  Back to cited text no. 3
Huang SC, Hua DJ, Sun QQ, Zhang LN, Cen H, Zhou L. Associations of TRAF1/C5 rs10818488 and rs3761847 polymorphisms with genetic susceptibility to rheumatoid arthritis: a case-control study and updated meta-analysis. Cent Eur J Immunol 2019; 44:159–173.  Back to cited text no. 4
Joob S, Guran M. Interleukin-18 gene polymorphism and susceptibility of condyloma acuminatum. Adv Trop Med Pub Health Int 2019; 9:42–43.  Back to cited text no. 5


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