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 Table of Contents  
LETTER TO EDITOR
Year : 2020  |  Volume : 18  |  Issue : 2  |  Page : 111

Interleukin-6 gene polymorphism and rheumatoid arthritis


1 26 Medical Center, Bangkok, Thailand
2 Department of Community Medicine, Dr DY Patil University, Pune, India

Date of Submission24-Oct-2019
Date of Decision29-Oct-2019
Date of Acceptance20-Jan-2020
Date of Web Publication24-Jul-2020

Correspondence Address:
Rujittika Mungmunpuntipantip
26 Medical Center, Bangkok 10150
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/AZMJ.AZMJ_146_19

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How to cite this article:
Mungmunpuntipantip R, Wiwanitkit V. Interleukin-6 gene polymorphism and rheumatoid arthritis. Al-Azhar Assiut Med J 2020;18:111

How to cite this URL:
Mungmunpuntipantip R, Wiwanitkit V. Interleukin-6 gene polymorphism and rheumatoid arthritis. Al-Azhar Assiut Med J [serial online] 2020 [cited 2020 Oct 20];18:111. Available from: http://www.azmj.eg.net/text.asp?2020/18/2/111/290600



Dear editor,

We read the publication on ‘Study of the effect of interleukin (IL)-6 gene polymorphism in patients with rheumatoid arthritis (RA)’ with great interest [1]. Sedira et al. [1] have noted that ‘The GC and CC genotype and C allele of IL-6 (−174G/C) may represent a significant genetic molecular marker to predict the risk of RA.’ Indeed, this study focused on single-gene polymorphism. There might be other effects from other genetic polymorphisms that might affect RA (such as APOE, HLA-G 3’UTR, and TRAF1/C5 polymorphisms) [2],[3],[4]. Regarding the effect of IL-6 (−174G/C), the molecular mechanism underlying the pathogenesis is the molecular change due to single mutation. As described in a previous study on IL-18 (−137G/C) [5], the G/C change results in decreased molecular weight equal to −40.03 g/mol. This pathobiological process is the same as that described in the study on the effect of IL polymorphism on other medical disorders [5].

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Sedira MH, Seoudy OA, Ahmed LA, El Attar S, Mohamed EF. Study of the effect of interleukin-6 gene polymorphism in patients with rheumatoid arthritis. Al-Azhar Assiut Med J 2019; 17:182–189  Back to cited text no. 1
    
2.
Gauri LA, Singh U, Kapur S, Fatima Q, Ranwa B, Khan A et al. Study of APOE gene and D2S439 marker in patients of rheumatoid arthritis and their correlation with severity of disease: a case control study. J Assoc Physicians India 2019; 67:43–48.  Back to cited text no. 2
    
3.
Gautam S, Kumar U, Kumar M, Kanga U, Dada R. Association of HLA-G 3’UTR polymorphisms with soluble HLA-G levels and disease activity in patients with rheumatoid arthritis: a case-control study. Immunol Invest 2019; 49:1–18.  Back to cited text no. 3
    
4.
Huang SC, Hua DJ, Sun QQ, Zhang LN, Cen H, Zhou L. Associations of TRAF1/C5 rs10818488 and rs3761847 polymorphisms with genetic susceptibility to rheumatoid arthritis: a case-control study and updated meta-analysis. Cent Eur J Immunol 2019; 44:159–173.  Back to cited text no. 4
    
5.
Joob S, Guran M. Interleukin-18 gene polymorphism and susceptibility of condyloma acuminatum. Adv Trop Med Pub Health Int 2019; 9:42–43.  Back to cited text no. 5
    




 

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