|LETTER TO EDITOR
|Year : 2020 | Volume
| Issue : 2 | Page : 111
Interleukin-6 gene polymorphism and rheumatoid arthritis
Rujittika Mungmunpuntipantip1, Viroj Wiwanitkit2
1 26 Medical Center, Bangkok, Thailand
2 Department of Community Medicine, Dr DY Patil University, Pune, India
|Date of Submission||24-Oct-2019|
|Date of Decision||29-Oct-2019|
|Date of Acceptance||20-Jan-2020|
|Date of Web Publication||24-Jul-2020|
26 Medical Center, Bangkok 10150
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Mungmunpuntipantip R, Wiwanitkit V. Interleukin-6 gene polymorphism and rheumatoid arthritis. Al-Azhar Assiut Med J 2020;18:111
We read the publication on ‘Study of the effect of interleukin (IL)-6 gene polymorphism in patients with rheumatoid arthritis (RA)’ with great interest . Sedira et al.  have noted that ‘The GC and CC genotype and C allele of IL-6 (−174G/C) may represent a significant genetic molecular marker to predict the risk of RA.’ Indeed, this study focused on single-gene polymorphism. There might be other effects from other genetic polymorphisms that might affect RA (such as APOE, HLA-G 3’UTR, and TRAF1/C5 polymorphisms) ,,. Regarding the effect of IL-6 (−174G/C), the molecular mechanism underlying the pathogenesis is the molecular change due to single mutation. As described in a previous study on IL-18 (−137G/C) , the G/C change results in decreased molecular weight equal to −40.03 g/mol. This pathobiological process is the same as that described in the study on the effect of IL polymorphism on other medical disorders .
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Conflicts of interest
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| References|| |
Sedira MH, Seoudy OA, Ahmed LA, El Attar S, Mohamed EF. Study of the effect of interleukin-6 gene polymorphism in patients with rheumatoid arthritis. Al-Azhar Assiut Med J 2019; 17:182–189
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Gautam S, Kumar U, Kumar M, Kanga U, Dada R. Association of HLA-G 3’UTR polymorphisms with soluble HLA-G levels and disease activity in patients with rheumatoid arthritis: a case-control study. Immunol Invest 2019; 49:1–18.
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