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ORIGINAL ARTICLE
Year : 2016  |  Volume : 14  |  Issue : 2  |  Page : 89-94

Study of predictive value of capillaroscopic pattern and serum level of interleukin-17 in rheumatoid vasculitis patients


1 Department of Physical Medicine, Rheumatology and Rehabilitation; Faculty of Medicine, Alexandria University, Alexandria, Egypt
2 Department of Internal Medicine; Faculty of Medicine, Alexandria University, Alexandria, Egypt
3 Department of Clinical Pathology; Faculty of Medicine, Alexandria University, Alexandria, Egypt
4 Department of Physical Medicine, Rheumatology and Rehabilitation, Alexandria University, Alexandria, Egypt

Correspondence Address:
Omneya E Elazzazy
Doctor degree in Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Alexandria University, Alexandria
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1687-1693.192647

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Objectives The aim of this study was to investigate nailfold capillaroscopic (NC) abnormalities and serum interleukin (IL)-17) level among rheumatoid arthritis (RA) patients with or without vasculitis. Patients and methods The study was carried on a group of RA Egyptian patients (n=40) who were diagnosed with RA based on ACR criteria. These 40 patients were further divided into two groups. Group 1 included RA patients with clinical signs of skin vasculitis and NC changes (n=6). Group 2 included RA patients with no clinical signs of skin vasculitis and no NC changes (n=34). All patients were subjected to demographic data collection, clinical examination, Disease Activity Score (DAS) 28 calculation, laboratory measurement (including erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, antinuclear antibody, antineutrophil cytoplasmic antibody, anticyclic citrullinated peptide, and IL-17), and NC examination. In addition, group 1 (n=6) was further subjected to electrophysiological evaluation by peripheral nerve conduction studies. Results Significantly elevated levels of IL-17 and characteristic NC changes were seen in RA vasculitis patients. Conclusion Rheumatoid vasculitis is associated with significantly elevated levels of serum IL-17 and characteristic NC changes.


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